Emotional pain could translate into stress. MGS4 had a stress meter that was affected by gameplay & actual cutscenes.
I was going for funny... But "incontinence"? Flash, you crazy..
Hardmode sounds good. But i would much rather if we had a full on full realism mode.
I'm not sure how well would that translate into a Cyberpunk game though.. First, you already have your humanity to deal with.. (Since cybernetic implants take away from your humanity) Also, if we have a meter for everything in the game, it could get boring real fast..