I don't mind so much having someone like Hideo Kojima in the game, he isn't part of the story or really interactable at all and he is a heavy influence on the gaming world and beyond so it is cool to honour the guy. Films have cameos like this all the time, Hitchcock put himself in his films all the time, Hunter S Thompson has a cameo in the film based upon his book. All cool.
However, having some chump with a YouTube channel having a role as themselves in the game is pretty crummy in my opinion. Why? Just because they're chummy with the company? It's fucking lame, it's like making a TV show filled with only in jokes that the writers get.
If someone from YouTube has a role in a game as a character that is fine, hell even if they're playing themselves in some memey self aware game that is lampooning or making a comment on internet culture, it ain't something I am interested in but that is fine, it's contextually relevent. Jesse Cox though, as himself? Stupid and pointless. I don't even like this guy's content though even if I did it would still be jarring.
Also on that note I hate the fact that Grimes is a character in this game. Don't like her music, don't like her as a person and she can't voice act for shit.