When the game launched I played it on normal difficulty for the first few dozen hours or so, then switched to death march as the game became so easy I could play it blindfolded.
Got about 149 hours played now, finished the main story a couple of days ago - past few days I've been just running around, doing some side quests and treasure hunts, but meh. Still a lot of parts on the map remain unexplored. Couple of hours ago I started a new game and this time on death march difficulty. So yeah, second playthrough now, and I will be going for a completionist one. Not one tree or shrubbery in the entire ploughing map will be left untouched.