I thought a bit about this new system, and now that we know that no major changes will be made to the system since it's very close to release, at least they can tweak it based on feedback, so here's mine, provided I don't know all the details.
I would prefer if only the currently equipped potions refill. You select 3 or 4 for example, that you are going to use, then while you have the required ingredients/alcohol when meditating those potions will refill, only them.
And say you'll have a limited uses of each potions, like 3-6, based on potion level and alchemy mastery.
If different potions could also somehow react with each other, having either positive or negative effect, it would be even better.
This also ties to the recommended potions for some quests, no matter if they are directly shown or the player has to determine on him/her self which they are. You'll prepare for a fight with only the ones you need, and as long as you have the materials, only they will refill.
The new mutagen system is also better in my opinion, in the W2, you had to wait till you find a top level mutagen before you decide to use one, and they were not that engaging in their use and effect.
Now if you can select up to 3 mutagens of your choice, with more profound effects and their own set of pros and cons, and be able to change them when you like, that would be great.
What would be even better, if for every time you decide to use a mutagen, you'll have to create it, thus you'll need ingredients. It would make you think what to use and not be too wasteful.
Now for the ingredients themselves, the system is pretty much the same, you'll gather them from monsters and plants, but I'd like some of the rare ones, to be fun to hunt or locate.
The hunt/discovery for ingredients for me is more fun than just the chose of gathering large amounts of them. As I previously mentioned in the W2 I had way to many ingredients so that I had to sell tons of them and I wasn't even trying, so I don't think the lack of ingredients made players not use it, it was that only some of them were useful, like really useful, so the rest went to the background.
Now if they can make more potions be a viable option in a more situations, this will make people use them more, not just on higher difficulties.
I have my fingers crossed that things turn out well and hope for some more videos detailing the skill and alchemy systems.
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I would at least like a hint before a major fight when to take potions so we don't get caught out. Just a comment like I should prepare.
I liked the preparation for combat in the W2, but it wasn't very flexible, especially on your first playthrough. You didn't know what to expect and it was basically trial and error. You die, you go back and just choose some different potions.
Now they are addressing this by allowing you to drink potions on the go, but what those potions should be is part of the preparation for the short term battles. The mutagens as well, though they are a bit more long term decisions.