The main point is that every fan intake should be filtered, and the filter should have fine enough mesh to catch most dust particles. Plus the pressure should be positive, otherwise the dust will be sucked in through various cracks and small openings all around the case. There are kits for well known cases, including Antec ones.
Example: http://www.demcifilter.com/p0392/Antec-902-Dust-Filter-Kit.aspx
You can put these instead of your internal filters if combining them is too much. Then figure out if you need to redirect some big fans inside rather than outside to make the pressure in the case positive (that what I had to do - reversing one out of two 20 cm fans so both started blowing inside the case). Just avoid making pressure too unbalanced - it would put strain on the fans and reduce the ventilation effect. It should be just slightly positive.
Example: http://www.demcifilter.com/p0392/Antec-902-Dust-Filter-Kit.aspx
You can put these instead of your internal filters if combining them is too much. Then figure out if you need to redirect some big fans inside rather than outside to make the pressure in the case positive (that what I had to do - reversing one out of two 20 cm fans so both started blowing inside the case). Just avoid making pressure too unbalanced - it would put strain on the fans and reduce the ventilation effect. It should be just slightly positive.
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