No...just no...no Master Chief, he's a super space marine.
No Commander Shepard, he has no cybernetics or personality.
Maybe Adam Jensen since he does some cyberpunk in him and his game...or just make fun of how small DE:HR is.
As for Cyborg, I'm torn though I'd toss in a Stark Enterprises or something Iron Man related.
I could see them tossing in a cyberoptic resembling 7-of-9's eyebrow thingy.