I think it's about " to take enough info about the monster, use the right weapon and drink the right potion".This doesn't cover the entire Q&A, just a few of them.
He gives some insight about the werewolf battle at around 13:00, saying that the fight looked easy at first because,
(1) It was on Easy mode.
(2) The player was well prepared.
In another playthrough when the player wasn't prepared he nearly died, on the same level. I think he was referring to the Russian 35min, where the werewolf almost killed him. I'm not quite sure in what way he "wasn't prepared" though, to be honest.