The game gives you a fair amount of options for playing non-lethal, flashbangs, non-lethal takedowns, you can even get cyberware to make your smartguns non-lethal. But what is the point? It doesn't seem to affect anything in the story outside of maybe one fight and it doesn't seem to affect anyone's opinions about V. Just something I noticed today. It might be cool if there were things that got affected by whether or not V actually gives a damn about human life.